Christof Regl's and Therese Wohlschlager's insights into the characterization of methionine oxidation in Rituximab by HPLC-MS have been collected in a Case Study entitled A Platform Method for Oxidation Monitoringin Monoclonal Antibodies and Fc-FusionProteins — A Biopharmaceutical Method Development Case Study, available from the Thermo Fisher Scientific website. Thanks Rowan Moore and Stacy Tremintin for the collaboration!

Therese Wohlschlager's publication Native mass spectrometry combined with enzymatic dissection unravels glycoform heterogeneity of biopharmaceuticals in Nature Communications has been recognized with the Publication of the Month Award of the Department of Biosciences. Open access article can be found here.

Again, pharma/biopharma was a hot topic at the 42nd ISCC in Riva del Garda. Using data elaborated by Christof Regl and Therese Wohlschlager, Christian Doppler Laboratory Head Christian Huber presented a critical check on the capabilities of chromatography and mass spectrometry with respect to revealing oxidation in biopharmaceuticals. Details will follow soon in a short article to be published in the LCGC Biopharmacuetical Perspectives Column.

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Therese Wohlschlager's findings on the plurality of protein isoforms of Etanercept triggered Neil Kelleher's (Northwestern University) interest and resulted in an invitation to contribute to a large collaborative perspective article in Nature Chemical Biology dealing with the essential question "how many proteoforms are there?"
Nature Chemical Biology volume 14, pages 206–214 (2018)

Aebersold R., Agar J. N., Amster I. J., Baker M. S., Bertozzi C. R., Boja E. S., Costello C. E., Cravatt B. F., Fenselau C., Garcia B. A., Ge Y., Gunawardena J., Hendrickson R. C., Hergenrother P. J., Huber C. G., Ivanov A. R., Jensen O. N., Jewett M. C., Kelleher N. L., Kiessling L. L., Krogan N. J., Larsen M. R., Loo J. A., Ogorzalek Loo R. R., Lundberg E., MacCoss M. J., Mallick P., Mootha V. K., Mrksich M., Muir T. W., Patrie S. M., Pesavento J. J., Pitteri S. J., Rodriguez H., Saghatelian A., Sandoval W., Schlüter H., Sechi S., Slavoff S. A., Smith L. M., Snyder M. P., Thomas P. M., Uhlén M., Van Eyk J. E., Vidal M., Walt D. R., White F. M., Williams E. R., Wohlschlager T., Wysocki V. H., Yates N. A., Young N. L., Zhang B.
How many human proteoforms are there?
Nat. Chem. Biol. 14(3), 206–214 (2018)

Zauner F. B., Dall E., Regl C., Grassi L., Huber C. G., Cabrele C., Brandstetter H.
Crystal structure of plant legumain reveals a unique two-chain state with pH-dependent activity regulation
Plant Cell 2018-02-16 (Epub ahead of print)