Symposium of the doctoral college Immunity in Cancer and Allergy and the Doctoral School PLUS Biomolecules at the University of Salzburg. Christian Doppler Lab members Michael Kohlberger and Arthur Hinterholzer publicly presented their dissertation projects during the symposium: Identification of Aptamers for Host Cell Protein Detection (supervision: Fatima Ferreira-Briza und Gabriele Gadermaier) and Detection and quantification of post-translational modifications in biopharmaceuticals with NMR-Spectroscopy (supervision: Chiara Cabrele und Mario Schubert). Well done!

180703 symposium

Christof Regl's and Therese Wohlschlager's insights into the characterization of methionine oxidation in Rituximab by HPLC-MS have been collected in a Case Study entitled A Platform Method for Oxidation Monitoringin Monoclonal Antibodies and Fc-FusionProteins — A Biopharmaceutical Method Development Case Study, available from the Thermo Fisher Scientific website. Thanks Rowan Moore and Stacy Tremintin for the collaboration!

Therese Wohlschlager's publication Native mass spectrometry combined with enzymatic dissection unravels glycoform heterogeneity of biopharmaceuticals in Nature Communications has been recognized with the Publication of the Month Award of the Department of Biosciences. Open access article can be found here.

Again, pharma/biopharma was a hot topic at the 42nd ISCC in Riva del Garda. Using data elaborated by Christof Regl and Therese Wohlschlager, Christian Doppler Laboratory Head Christian Huber presented a critical check on the capabilities of chromatography and mass spectrometry with respect to revealing oxidation in biopharmaceuticals. Details will follow soon in a short article to be published in the LCGC Biopharmacuetical Perspectives Column.

180523 iscc

P.I.s, PostDocs and PhD students of the bioanalytical labs of Salzburg, Kiel, and Strasbourg met for the first time in Strasbourg to discus and exchange methods of protein analytis and characterization mostly in the biopharma area.

180309 sks meeting 1

Our host, Sarah Cianferani, with our guest star, Alain Beck, in the back, who kindly joined the meeting via video conference, giving a very interesting overview about curent status of biopharmaceutical developemnt and analytical challenges involved. The group decided to hold the next meeting in March 2018 in Salzurg.

180309 sks meeting 2

Good ideas best grow on the basis of a nice and communicative dinner! Strasbourg is a great place to get inspired!

180309 sks meeting 3