Symposium of the doctoral college Immunity in Cancer and Allergy and the Doctoral School PLUS Biomolecules at the University of Salzburg. Christian Doppler Lab members Michael Kohlberger and Arthur Hinterholzer publicly presented their dissertation projects during the symposium: Identification of Aptamers for Host Cell Protein Detection (supervision: Fatima Ferreira-Briza und Gabriele Gadermaier) and Detection and quantification of post-translational modifications in biopharmaceuticals with NMR-Spectroscopy (supervision: Chiara Cabrele und Mario Schubert). Well done!

180703 symposium

Christof Regl's and Therese Wohlschlager's insights into the characterization of methionine oxidation in Rituximab by HPLC-MS have been collected in a Case Study entitled A Platform Method for Oxidation Monitoringin Monoclonal Antibodies and Fc-FusionProteins — A Biopharmaceutical Method Development Case Study, available from the Thermo Fisher Scientific website. Thanks Rowan Moore and Stacy Tremintin for the collaboration!

Therese Wohlschlager's publication Native mass spectrometry combined with enzymatic dissection unravels glycoform heterogeneity of biopharmaceuticals in Nature Communications has been recognized with the Publication of the Month Award of the Department of Biosciences. Open access article can be found here.

Again, pharma/biopharma was a hot topic at the 42nd ISCC in Riva del Garda. Using data elaborated by Christof Regl and Therese Wohlschlager, Christian Doppler Laboratory Head Christian Huber presented a critical check on the capabilities of chromatography and mass spectrometry with respect to revealing oxidation in biopharmaceuticals. Details will follow soon in a short article to be published in the LCGC Biopharmacuetical Perspectives Column.

180523 iscc

Christian Huber presents recent work of Christof Regl and Therese Wohlschlager in the area of molecular characterization of Rituximab oxidation and Etanercept glycosylation at the well-attended Thermo Scientific Biopharma Summit: Shaping the future Together in Vienna on March 1st, 2018. Obviously, attendents were most interested in the details of mass spectrometric analysis of protein therapeutics by native mass spectrometry and the chromatographic separation of oxidozed Fc/2 fragments of IgG1 antibodies. For full program, see here.
Moreover, Veronika Reisinger from Sandoz GmbH, who also collaborates with the Christion Doppler Laborotory, presented her insights into host-cell protein analysis via HPLC-MS/MS.