Last week, CD Lab scientists attended the ANAKON conference in Münster/Germany. Highlights, among a number of highly interesting presentations dealing with analytical sciences were:

  1. The chairman of the conference, Prof. Uwe Karst, receiving the Hans-Malissa-Sen.-Lecture Award of the Austrian Society of Analytical Chemistry.
  2. Dr. Stefan Lamotte, BASF, receiving the Gerhard Hesse Award of the German Chemical Society/Working Group Separation Science.
  3. Constantin Blöchl presenting his work in a lecture entitled Middle-Up Analysis of Murine IgG Reveals Changes in N-Glycosylation upon Antigen Vaccination. This lecture has been recognized with the Agnes and Isván Halász Young Scientist Award. Congratulations Constantin!
  4. Christof Regl presenting his work Dilute-and-Shoot Analysis of Therapeutic Monoclonal Antibody Variants in Fermentation Broth: A Method Capability Study.
  5. Christian Huber talking about The Search for Impurities in Low- and High-Molecular Pharmaceuticals: Two Different Worlds.

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The symposium Celebration of Native Mass Spectrometry was held in Oxford, 24-26th March 2019, with 160 participants. Prof. Carol Robinson opened the conference with a plenary lecture entitled Native MS – Past, Present, Future. The symposium covered the application of native MS in structural biology, biopharma characterization and membrane protein analysis, as well as theoretical considerations on proteins in the gas phase. The last session provided an outlook on the future of structural MS, native top-down and new methods & workflows. Remain Creative with Native was the motto of the closing plenary lecture given by Prof. Albert Heck. Other talks: Ken Cook on chromatographic separation coupled to native mass spectrometry; Therese Wohlschlager on native MS unravelling highly complex glycosylation patterns in therapeutic proteins.

Mario Schubert's and colleagues' study into protein gluconoylation by denaturing NMR has been published in the Journal of Biomolecular NMR. Another convincing example of our multidisciplinary approach to protein biochemistry involving NMR spectroscopy, mass spectrometry, structural biology, and bioorganic chemistry. Full article is available here.

Lab head Christian Huber presented a tutorial lecture entitled Molecular Characterization of Biotherapeutic Proteins: Concepts and Challenges for Separation Science and Mass Spectrometry at the 47th International Symposium on High-Performance Liquid Phase Separations and Related Techniques in Washington D.C. In spite of an early lecture on the first day of the Symposium, the event was quite well attended, reflecting broad interest of HPLC attendants for biopharmaceutical analysis.
 
Highlights of the Symposium were:
  • The chairman of the Symposium, Norman Dovichi, following the old tradition of opening the Symposium by ringing the old cowbell of the first Symposium in Interlaken (1973).
  • Chris Pohl from Thermo Fisher Scientific receiving the Uwe D. Neue Award in Separation Science sponsored by Waters Corporation.
  • Jonathan Bones from NIBRT talking about the separation of charge variants of biotherapeutics by pH-gradient cation-HPLC and characterization by mass spectrometry.
  • Christian Huber meeting Fred Regnier, one of his most prominent teachers in stationary phase chemistry and basics of DNA and protein chromatography and real pioneer of HPLC of biomolecules.
Next Symposium will be organized 2019 in Milano/Italy.
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