Christof Regl's and Therese Wohlschlager's study into the performance characteristics of HPLC-MS for analyzing multiple attributes of therapeutic antibodies at the intact protein level was accepted for publication in mAbs. The study was initiated by Johann Holzmann and first experiments were performed quite some time ago by Iris Wagner and Martin Samonig.

Another opportunity to tell the story of antibody characterization by HPLC-MS methods. Remarkably, the organizer of the conference, Frantisek Foret, was honored with the Csaba Horváth Memorial Lectureship Award presented by the American Chemical Society (on the picture together with Andras Guttmann and Ference Darvas, President of the Awards Committee American Chemical Society Hungary Chapter). Congratulations!
The group picture (lower right) shows Csaba Horváth's group from 1996 in New Haven, when Frantisek was still associated with the Barnett Institute of Northeastern University in Boston, only 150 miles away from Csaba's labs at Yale University.
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Lab head Christian Huber presented a tutorial lecture entitled Molecular Characterization of Biotherapeutic Proteins: Concepts and Challenges for Separation Science and Mass Spectrometry at the 47th International Symposium on High-Performance Liquid Phase Separations and Related Techniques in Washington D.C. In spite of an early lecture on the first day of the Symposium, the event was quite well attended, reflecting broad interest of HPLC attendants for biopharmaceutical analysis.
Highlights of the Symposium were:
  • The chairman of the Symposium, Norman Dovichi, following the old tradition of opening the Symposium by ringing the old cowbell of the first Symposium in Interlaken (1973).
  • Chris Pohl from Thermo Fisher Scientific receiving the Uwe D. Neue Award in Separation Science sponsored by Waters Corporation.
  • Jonathan Bones from NIBRT talking about the separation of charge variants of biotherapeutics by pH-gradient cation-HPLC and characterization by mass spectrometry.
  • Christian Huber meeting Fred Regnier, one of his most prominent teachers in stationary phase chemistry and basics of DNA and protein chromatography and real pioneer of HPLC of biomolecules.
Next Symposium will be organized 2019 in Milano/Italy.
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