Last week, CD Lab scientists attended the ANAKON conference in Münster/Germany. Highlights, among a number of highly interesting presentations dealing with analytical sciences were:
The chairman of the conference, Prof. Uwe Karst, receiving the Hans-Malissa-Sen.-Lecture Award of the Austrian Society of Analytical Chemistry.
Dr. Stefan Lamotte, BASF, receiving the Gerhard Hesse Award of the German Chemical Society/Working Group Separation Science.
Constantin Blöchl presenting his work in a lecture entitled Middle-Up Analysis of Murine IgG Reveals Changes in N-Glycosylation upon Antigen Vaccination. This lecture has been recognized with the Agnes and Isván Halász Young Scientist Award. Congratulations Constantin!
Christof Regl presenting his work Dilute-and-Shoot Analysis of Therapeutic Monoclonal Antibody Variants in Fermentation Broth: A Method Capability Study.
Christian Huber talking about The Search for Impurities in Low- and High-Molecular Pharmaceuticals: Two Different Worlds.
The symposium Celebration of Native Mass Spectrometry was held in Oxford, 24-26th March 2019, with 160 participants. Prof. Carol Robinson opened the conference with a plenary lecture entitled Native MS – Past, Present, Future. The symposium covered the application of native MS in structural biology, biopharma characterization and membrane protein analysis, as well as theoretical considerations on proteins in the gas phase. The last session provided an outlook on the future of structural MS, native top-down and new methods & workflows. Remain Creative with Native was the motto of the closing plenary lecture given by Prof. Albert Heck. Other talks: Ken Cook on chromatographic separation coupled to native mass spectrometry; Therese Wohlschlager on native MS unravelling highly complex glycosylation patterns in therapeutic proteins.
Mario Schubert's and colleagues' study into protein gluconoylation by denaturing NMR has been published in the Journal of Biomolecular NMR. Another convincing example of our multidisciplinary approach to protein biochemistry involving NMR spectroscopy, mass spectrometry, structural biology, and bioorganic chemistry. Full article is available here.
The Nature Communications paper on the study of Etanercept glycosylation by native MS has been proposed as 2018 landmark paper by The Analytical Scientist. Thanks to Andrea Gargano and The Analytical Scientist for recognizing the work of the Christian Doppler Laboratory!
The comprehensive investigation of method capability using HPLC-MS for monitoring multiple molecular attributes of monoclonal antibodies during fermentation has been published in mAbs. Congratulations to the co-authors!
For the 14th time, researchers and stakeholders of the Christian Doppler Laboratory met to exchange progress made and discuss new ideas. Thanks to Rowan Moore and Frank Steiner for hosting this meeting at the Thermo Fisher Scientific site in Germering!